Awakenings

"The victims of an encephalitis epidemic many years ago have been catatonic ever since, but now a new drug offers the prospect of reviving them."

imdb.com

Dr. Sayer: The human spirit is more powerful than any drug and that is what needs to be nourished with work, play, friendship, family. THESE are the things that matter. This is what we'd forgotten - the simplest things.

Tootsie

"An unemployed actor with a reputation for being difficult disguises himself as a woman to get a role in a soap opera."

imdb.com

Jeff: I'm just afraid that you're going to burn in Hell for all this.

Michael: I don't believe in hell. I believe in unemployment, but I don't believe in hell.